Objectives of the meeting

This workshop builds on the successes and identified challenges from two prior workshops on the subject of human challenge trials or controlled human infection models (CHIM).  When CHIM are used to inform vaccine development, they can add to what is known from natural history, epidemiology, and pathogenesis studies to speed the vaccine development pathway.  However, there are significant safety, ethical, operational, environmental, and scientific issues in intentionally infecting humans with infectious organisms in controlled settings of clinical trials.  Nonetheless, these trials can be performed safely and ethically both in non-endemic and endemic regions.  Attend this workshop to learn more about these challenging issues and to join in the conversation that will lead to progress and recommendations for enhancing CHIM as tools to develop new and improved vaccines

Scientific Committee

  • Andrew Pollard, co-Chair Scientific Committee; University of Oxford, United Kingdom
  • Robert Sauerwein, co-Chair Scientific Committee, Radboud University Medical Center, Nijmegen, The Netherlands
  • Pieter Neels, Chair Human Vaccine Committee, International Alliance for Biological Standardization (IABS)
  • Ivana Knezevic, World Health Organization, Geneva, Switzerland
  • Rebecca Sheets, International Alliance for Biological Standardization (IABS), U.S.A.
  • Claudia Emerson, McMaster University, Hamilton, Ontario, Canada
  • Marc Gurwith, PaxVax Inc., San Diego, California, U.S.A.
  • Anna Durbin, Johns Hopkins Bloomberg School of Public Health, U.S.A.
  • William Ripley Ballou, GlaxoSmithKline, U.S.A.
  • Martin Broadstock, Medical Research Council, United Kingdom
  • Helen McShane, University of Oxford, United Kingdom
  • Paul Kaye, University of York, United Kingdom
  • Kirsty E.K Mehring-Le Doare, Imperial College of London, United Kingdom
  • Peter J.M. Openshaw, Imperial College of London, United Kingdom
  • Daniela Ferreira, Liverpool School of Tropical Medicine, United Kingdom
  • Adrian Wildfire, S.G.S., United Kingdom